Synthetic organic, inorganic and organometallic chemistry, transition metal catalyzed asymmetric reactions for the synthesis of biologically active compounds, biomimetic chemistry, molecular recognition and material chemistry.
Dr. Xumu Zhang
Professor of Department of Chemistry, Pennsylvania State University
Guest Professor of Shanghai Institute of Organic Chemistry
Guest Professor of Dalian Institute of Chemical Physics
Guest Professor of Wuhan University
B.S., Wuhan University, 1982
M.S., Chinese Science Academy, 1985
Ph.D., Stanford University, 1992
Awards and Fellowships:
Franklin Veatch Graduate Fellowship, 1991, Stanford University
The Camille and Henry Dreyfus Foundation New Faculty Award, 1994
DuPont Young Faculty Award, 1996
Office of Naval Research Young Investigator Award, 1996
The Camille and Henry Dreyfus Foundation Teacher-Scholar Award, 1998
The John Simon Guggenheim Foundation Fellow, 2000
The Outstanding Oversea Chinese Young Scientist B, Chinese Academy of Sciences, 2000
The Penn State Faculty Scholar Medal, 2001
The Young Innovation Award of ChiTec (Chinese High Tech) in Chemistry, 2001
The American Chemical Society Arthur C. Cope Scholar Award, 2002
The SDCA (San Diego Chinese Association) Achievement Award, 2002
The Founder and Chief Technology Officer of Chiral Quest, Inc.
The central theme of Professor Zhang's research is the development of novel transition metal-based catalysts for enantioselective organic transformations. A growing demand in pharmaceutical industries is to make a chiral drug in enantiomerically pure form. During the last several decades, chemists have made major progress in discovering man-made catalysts to perform challenging asymmetric transformations. However, there is no universal chiral ligand or catalyst for solving problems in enantioselective transformations. The focus of Zhang's research is to develop a useful chiral toolbox (n ligands) for strategically important asymmetric catalytic reactions (m reactions) by inventing a diverse set of novel chiral ligands and combining them with transition metals as effective enantioselective catalysts. The toolbox approach addresses the fundamental problems in organic stereochemistry and will result in practical methods for the synthesis of chiral pharmaceuticals and agrochemicals.
Zhang's research group has developed several new bidentate phosphine ligands for asymmetric catalysis. The common feature of these ligands is that they contain rigid aromatic backbones or ring structures that could be used to restrict conformational flexibility of the ligands, and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity. The following reactions have been studied: asymmetric hydrogenation of functionalized substrates such as N-acylaminoacrylic acids, enamides, enol acetates; asymmetric hydrogenation of simple olefins, ketones, and imines; and asymmetric carbon-carbon bond formation reactions.
Novel chiral heterobicyclo[2.2.1]heptanes have been developed as catalysts or auxiliaries for enantioselective organic transformations. Transition metal catalysts with a variety of chiral monophosphines are under investigation.
The first Rh-catalyzed enyne isomerization has been discovered, and highly enantioselective Rh-catalyzed ene reaction has been realized. High throughput methods have been used to explore new transition metal catalyzed reactions and asymmetric catalysis.
2002年美国化学会国家奖获得者 (ACS 2002 National Award Recipients)
Summary by 杨宏伟 on 2003-12-09
Last updated by 杨宏伟 on 2003-12-09