美国能源部布鲁克海文国家实验室图像与神经科学研究中心：Joanna S. Fowler教授的研究小组
In has taken many years to conceptualize addiction as a disease of the brain which has similarities to many other chronic and relapsing illnesses. Many of the major advances in understanding how drugs of abuse affect the human brain as well as the delineation of brain circuits which are disrupted in addiction have come from molecular imaging. Advances in radiotracer design, chemistry and quantitation have made it possible to image dopamine and other neurotransmitter systems and to assess their role in behavior, in disease and in mediating the actions of drugs of abuse.1,2. They have used positron emission tomography (PET) imaging and carbon-11 labeled radiotracers which selectively bind to the dopamine transporter, the dopamine D2 receptor and monoamine oxidase (MAO) to probe the effects of drugs of abuse on the human brain. Many of these studies have been coupled with PET measures of brain function using 18FDG, a fluorine-18 labeled glucose deriv
ative which measures brain glucose metabolism in all brain regions simultaneously. This multi-tracer approach has provided new insights on the brain circuits which are linked to the behavioral changes in human addiction and has suggested new approaches to treatment.
Fowler is a world leader in the synthesis of compounds labeled with short-lived positron emitters for positron emission tomography.
She has contributed to the synthesis and application of short-lived radiolabeled compounds for use with imaging techniques such as positron emission tomography (PET); and, in particular, to people's understanding of the biochemical processes in addiction, aging and drug action.
Brookhaven Center for Imaging and Neuroscience
Brookhaven National Laboratory
Upton, NY 11973-5000
Phone: (631) 344 4365
2002年美国化学会国家奖获得者 (ACS 2002 National Award Recipients)
Summary by 何莉 on 2003-10-23
Last updated by 何莉 on 2003-10-23