ChIN简介页:美国斯坦福大学化学系:Barry M. Trost 教授的研究小组
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美国斯坦福大学化学系:Barry M. Trost 教授的研究小组


     Professor Trost’s work has been characterized by a very high order of imagination, innovation and
scholarship. He has ranged over the entire field of organic synthesis, particularly emphasizing
extraordinarily novel methodology. Further, he has repeatedly demonstrated how his innovative
methodology allows for the simplification of many complex target oriented syntheses leading to natural
products of high biological activity. Early in his career, Professor Trost participated in the isolation and
structure determination of the Cecropria Juvenile hormone. These studies helped to promulgate the
concept that insect growth regulators can serve as ecologically preferable alternatives to pesticides.

The long
term goal and defining mission of Professor Trost’s career has been toward enhancing synthetic
effectiveness. He has virtually created whole new methodologies and strategies in organic synthesis.
Among the areas which he has pioneered are the use of sulfur based reagents and transition metal, most
notably palladium, and more recently ruthenium, catalysts in complex setting. More recently, his work has
focused on enantioselective catalysts via the rational design of “chiral space.” This work requires a detailed
grasp of the mechanistic nuances of organometallic reactions. As part of this program, he designed a new
class of ligands that spontaneously forms dinuclear complexes that are proving to be especially effective at
asymmetric catalysis. Another continuing theme, directed to the realities of organic synthesis in fostering
commercial goals, is the strategy of “atom economy.” Thus, synthetic building blocks are combined to
produce complex targets in high yield with a bare minimum of debris under the guidance of carefully crafted
catalysts. In this way, organic synthesis can be brought to bear in process settings to reach substances of
high complexity in a commercially feasible way which minimizes environmental impact. Barry Trost’s
triumphs in total synthesis include complex terpenoids, steroids, alkaloids, vitamins, antibiotics,
nucleosides and macrolides. His syntheses are conducted with characteristic flair and serve as learning
resources in addressing the limits of the methodology which he tends to develop independently.

In recognition of his many contributions, Professor Trost has received a number of awards, including
the ACS Award in Pure Chemistry (1977), the ACS Award for Creative Work in Synthetic Organic Chemistry
(1981), the Baekeland Award (1981), the first Allan R. Day Award of the Philadelphia Organic Chemists' Club
(1983), the Chemical Pioneer Award of the American Institute of Chemists (1983), the Alexander von
Humboldt Stiftung Award (1984), MERIT Award of NIH (1988), Hamilton Award (1988), Arthur C. Cope
Scholar Award (1989), Guenther Award in the Chemistry of Essential Oils and Related Products (1990), the
Dr. Paul Janssen Prize (1990), the ASSU Graduate Teaching Award (1991), Pfizer Senior Faculty Award
(1992), Bing Teaching Award (1993), the ACS Roger Adams Award (1995), the Presidential Green Chemistry


Professor Barry M. Trost
Chemistry Department
Stanford University
Stanford, CA 94305-5080

tel: (650)723-3385

  第18届杂环化学国际大会 (2001-08-10)
  2002年美国化学会国家奖获得者 (ACS 2002 National Award Recipients)

Summary by 何莉 on 2003-09-10

Last updated by 何莉 on 2003-09-12

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