美国国家卫生研究所 (NIH)生物有机实验室：John W. Daly的研究小组
Daly is the world's leader in isolating novel chemicals from natural sources and utilizing them to characterize major aspects
of signal transduction.
Research has encompassed the fields of biogenic amines, including formation, metabolism and action, and effects of structural modifications on biological activity; drug metabolism with emphasis on oxidative pathways, leading to the discovery and elucidation of the "NIH Shift"; the control and interrelationship of cyclic nucleotide and phosphoinositide metabolism in brain tissue; the development of selective and potent agonists and antagonists for adenosine receptors, the mechanisms underlying central effects of xanthines; the delineation of the molecular basis (activation of adenylate cyclase) for the biological activity of the diterpene forskolin; and structure elucidation and definition of molecular basis for biological activity of natural products, in particular alkaloids (batrachotoxin, histrionicotoxin, pumiliotoxin, epibatidine) from tropical frogs and marine toxins (maitotoxin) with activity at ion channels.
Dr. Daly holds memberships in numerous scientific organizations and is on the editorial board of the Journals; Molecular Pharmacology, Cellular and Molecular Neurobiology, and Toxicon.
John has receive numerous honors including (in 1996) the Award for Outstanding Achievement in the Biological Sciences (Washington Academy of Sciences), the Outstanding Performance Award (Senior Executive Service, HHS), and the Japanese Society Fellowship for the Promotion of Science.
Dr. Daly has published nearly 500 research articles, numerous reviews and book chapters. He holds six patents and one monograph. He has delivered numerous invited and plenary lectures at National and International Scientific Meetings over his career.
Building 8, Room 1A17
Bethesda, MD 20892
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FAX: 301 402 0008
2002年美国化学会国家奖获得者 (ACS 2002 National Award Recipients)
Summary by 何莉 on 2003-10-23
Last updated by 何莉 on 2003-10-23