美国加州大学圣地亚哥分校药理学系：Roger Y. Tsien的研究小组
Signal Transduction; Calcium; Neurobiology;
Regulation and role of messengers such as calcium, cyclic AMP, and nitric oxide.
The goal of Tsien laboratory is to gain a better understanding of information processing, both inside individual living cells and in networks of neurons. They design, synthesize, and use new molecules that detect or manipulate intracellular biochemical signals. Their most versatile mechanism of transducing biochemical events into fluorescence color changes is a quantum mechanical phenomenon called fluorescence resonance energy transfer (FRET). FRET is a general way to detect when fluorophores get within nanometers, i.e., molecular dimensions, of each other. Nondestructive, quantifiable, and biophysically well-understood, FRET has very high resolution in time and space. The challenge is to engineer molecules in which the distance or orientation between the fluorescent partners is specifically sensitive to the desired biochemical signal or event. Ideally the molecules are genetically encodable, because such molecules can be introduced into many intact
organisms and targeted to specific tissues, cells, or subcellular locations.
Tsien has been receiving prizes for his work since as far back as 1968, including the W. Alden Spencer Award in Neurobiology from the University of Columbia (1991) and the Pearse Prize from the Royal Microscopical Society (2000). Since 1998 he has been a member of the National Academy of Sciences of the United States.
HHMI - UCSD
9500 Gilman Dr
CMM West 310
La Jolla, CA 92093-0647
(858) 534-7009 Lab
(858) 534-5268 Lab
(858) 534-4891 Office
2002年美国化学会国家奖获得者 (ACS 2002 National Award Recipients)
Summary by 何莉 on 2003-09-30
Last updated by 何莉 on 2003-09-30